Successful satellite design and operation requires proper understanding of the many plasma phenomena associated with spaceflight. Various types of plasma discharges affect satellite components on-orbit, and in some cases, they can lead to critical failures in susceptible hardware. Some key examples of these phenomena are electrostatic discharge (ESD), plasma propulsion effects, and RF/microwave plasma discharges. The Aerospace Corporation's Electric Propulsion and Plasma Science Section continues to experimentally research these areas to improve current understanding and provide necessary data to avoid potential satellite failures. In this talk, the plasma physics and mitigation strategies associated with the aforementioned plasma discharges will be discussed. Additionally, the unique experimental capabilities and techniques developed in Aerospace laboratories will be described with specific emphasis on how the data are used to improve satellite design and operation. Recent experiments include laboratory ESD formation and measurement on solar panel coupons, NASA's Evolutionary Xenon Thruster (NEXT) plume measurements, satellite communication and plasma thruster electromagnetic interference, and the effect of surface contamination on multipactor discharge.